Andrey Rublev's Monte Carlo Masters title defence ended at the first hurdle on Wednesday with a straight-sets defeat by Australian Alexei Popyrin, while Jannik Sinner eased through.
The Russian never got going in the second-round tie as Popyrin eased to a 6-4, 6-4 win at the traditional clay court warm-up for the French Open.
The world number 46 will face compatriot Alex de Minaur, who beat Tallon Griekspoor in three sets, for a possible quarter-final against Novak Djokovic.
