Kawhi Leonard and Paul George did Los Angeles' heavy lifting before James Harden took over to extend the Clippers' winning streak to an NBA-best eight games.
Harden scored 21 of his season-best 35 points in the fourth quarter and the Clippers got 28 points from Leonard and 27 from George to rout Indiana 151-127 on Tuesday (AEST) for their league-best eighth consecutive victory.
Harden shot 12-of-16 from the field and eight of 11 from deep, adding nine assists in his most efficient performance since being acquired from Philadelphia in October.