Melbourne have steamed past an injury-ravaged Brisbane by 56 points to claim a perfect 3-0 start to the AFLW season.
Elsewhere, Port Adelaide (2-1) lost star forward Indy Tahau to a suspected serious knee injury, overshadowing a thrilling four-point win over GWS in Canberra.
Tahau, who previously tore her left ACL, was helped off with a right knee injury late in the third quarter of Port Adelaide's 7.10 (52) to 8.0 (48) victory at Manuka Oval.
"It's difficult. Indy's such a great player for us. Obviously she's still being assessed and we hope for the best," coach Glenn Strachan told Fox Footy.
It was tight all day and Port led by nine at three-quarter time, before Brodee Mowbray goaled twice to put GWS in front.
The Giants led at the death, when Port's Matilda Scholz took a terrific intercept mark to create a late attack that ended with Lauren Young marking and kicking the winner.
"It's so funny, we actually practised this at training, this scenario," Young told Fox Footy.
"I was thinking, 'OK, I got it at training, I should be able to get it now'. And then I slotted it, so I'm very happy about that."
Scholz (30 hitouts, 24 disposals) was dominant, while Piper Window kicked three goals.
Alyce Parker (21 disposals) was busy for GWS (1-2).
Brisbane grabbed the first goal, but the Demons kicked the next 12 and handed the Lions their heaviest AFLW defeat, a 14.5 (89) to 4.9 (33) shellacking at Casey Fields.
Tom Wilson's Melbourne loom as a team who can genuinely challenge two-time reigning premiers North Melbourne.
Liv Purcell (31 disposals) and Tyla Hanks (24 disposals, eight tackles and a goal) were magnificent, while Kate Hore (24) was prolific and Tahlia Gillard (11 intercepts) led an impressive defence.
Ryleigh Wotherspoon (three goals, eight tackles), Georgia Gall (two), Mia Austin (two) and Megan Fitzsimon (two) hit the scoreboard.
Lions Marlow Graham (concussion) and Neesa Dooley (collarbone) were both hurt in the first quarter.
Then Belle Dawes (right shoulder) and Ruby Svarc (concussion) were worse for wear after colliding with each other.
Dawes played through pain and finished with 24 disposals and a goal, while Orla O'Dwyer (21) was strong.
Sophie Conway (left knee) and Eleanor Hartill (foot) also played through issues.
Later at Victoria Park, Hawthorn (2-1) claimed a 8.6 (54) to 3.8 (26) win over winless Collingwood. Hawthorn's Aine McDonagh kicked three goals, and Lucy Wales (23 disposals, 22 hitouts), Eliza West (23 possessions) and Jasmine Fleming were also influential.
Collingwood star Bri Davey was in tears after a right ankle injury scare in the first quarter but played out the game.
Ash Centra pushed through a corked left thigh, while Airlie Runnalls (22 disposals, nine tackles) was strong, along with Brittany Bonnici (22).
Forget rivalries or the race for competition points. In a week where football has been in the headlines for all the wrong reasons, the GWS Giants are a reminder of what is right.
Walk into coach Cam Bernasconi's final team meeting before their AFLW clash with Port Adelaide - which comes at Manuka Oval on Sunday - and you'll get an idea.
"We want to be a family club, so I always open my final team meeting to all families," Canberra product Bernasconi said.
This, coming from the same club that cast a rivalry aside and called on members to support the Sydney Swans' AFLW side at the SCG last weekend.
The result was a record crowd of 16,672 fans which more than doubled the Swans' previous benchmark.
The groundswell of support for the Swans' AFLW side came after five AFL players - Isaac Heeney, Chad Warner, Nick Blakey, Riley Bice and James Jordon - were suspended for the rest of the season for "breaching club standards".
A separate police investigation continues into an alleged sexual assault at East Melbourne's Pullman Hotel.
The Giants saw an opportunity to wrap their arms around their fiercest rival and show football is a safe space for women. They took it.
"Especially the way it came about, that was all player-driven. Our leadership group initiated that, which was really special," Bernasconi said.
"There's always good, healthy rivalry between us and Swans, but our players all wanted to get on the front foot and just wanted to make sure that their women's program was really supported.
"They all were really active on sharing it on social media. I think it certainly contributed to that great crowd they got, which was really great to see."
Now Canberra fans have a chance to show their support for women in football.
"The AFLW love playing in Canberra, and playing at stadiums," Bernasconi said. "It'd be awesome to see lots of orange in the grandstands."
Sunday's match at Manuka Oval brings Bernasconi back to the site of his own premiership success with Ainslie in the AFL Canberra competition.
So this one might mean a little more for the Giants coach, who has inked a two-year extension which keeps him at GWS until the end of the 2028 season.
"It's awesome coming home, having friends and family," Bernasconi said.
"When we travel, families tend to come and support, so they come [to team meetings] the night before. I always have my brother, niece and nephews, and my son now as well. It's a great little feel.
"It's really important to bring them along for the journey because they've been there the longest, families."
The Giants enter round three with one win in the bank, but the club is desperate to bounce back from a 48-point loss to the Melbourne Demons in round two.
It was the kind of result which exposed the gulf between the Giants' worst and a top side's best, and Bernasconi hopes a handful of fresh faces can help turn the tide.
"They've all been terrific. It's been a nice balance of senior players in Tilly [Lucas-Rodd] and Poppy [Boltz] coming in, and helping us immediately in a sense of their senior leadership," Bernasconi said.
"Our younger players as well, like having Yas [Janschek] and Kiera [Yerbury] debut last week and both playing important roles for us. It's been nice having some new faces, that new youthful energy, but also a sprinkle of senior experience, which is what we needed."
