
Jamie-Lynn Sigler, known for her role in The Sopranos, has been living with multiple sclerosis for two decades. When Christina Applegate received her own MS diagnosis, Sigler offered her advice and support, leading to a close friendship between the two actresses. Together, they launched a podcast called MeSsy, which provides a candid and humorous take on living with MS and the broader challenges they face.
Sigler, who kept her MS diagnosis hidden for 15 years before going public in 2016, admits to feeling shame and struggles with self-acceptance. She emphasizes the importance of physical therapy and daily workouts in managing the disease. Applegate, who discovered she had MS during the final season of her show Dead to Me, has been supportive of Sigler in embracing her condition and advocating for herself in the entertainment industry.