Australia's left-handed majority could prove crucial in their bid to conquer spin and win the series in South Africa, as the tourists eye off 288 for victory in Cape Town.
Pat Cummins' side will deal with a pitch offering little bounce and plenty of turn when they begin their chase on Saturday, with the series firmly on the line.
Simon Harmer looms as the main threat after taking 4-104 in the first innings, after also spinning South Africa to victory over India on a dry pitch in Guwahati last year.