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UNCOVERED: The new england journal of medicine | History Defined

Chronic Lower Back Pain Is a Core Strength Problem Your Posture Has Already Confirmed

Why Your Back Is Doing a Job It Was Never Meant to DoThe lumbar spine is a load-bearing structure, not a load-moving one. When the deep core muscles, specifically the transversus abdominis and multifidus, fail to activate correctly, the spine stops being a supported column and starts being a crane…

Times Life

Religious Fasting and Metabolic Health: What Navratri and Ekadashi Do to Your Insulin and Glucose

The Biology Starts Within Hours, Not DaysTwelve hours after your last meal, your liver glycogen is nearly depleted. At that point, the body shifts fuel sources: free fatty acids rise, and the liver begins producing ketone bodies. This is not a dramatic event, it happens quietly, every time a fast…

Times Life

5 Fasting Mistakes That Slow Your Metabolism and Make You Gain Weight Instead of Losing It

Eating Too Little for Too LongA 2022 study published in the New England Journal of Medicine found that extreme caloric restriction during fasting windows causes the body to down-regulate its resting metabolic rate within days, not weeks. The body reads a severe deficit as a famine signal. Muscle tissue breaks…

Times Life

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The Clinical Trial That Supported Tavneos for ANCA Vasculitis Was Just Retracted

NEJM retracted the Tavneos ADVOCATE trial on June 29, 2026, after FDA found altered patient data. Patients should not stop Tavneos without a doctor — here's what's known.

Medical Daily

Why Losing Weight Does Not Always Fix PCOS: What Hormones, Insulin, and Inflammation Actually Do

The Weight Loss Prescription Has a GapThe standard advice given to women with PCOS goes like this: lose 5 to 10 percent of your body weight and your symptoms will improve. That figure comes from real research. A 2007 study published in the New England Journal of Medicine by Legro…

Times Life

Paxlovid Speeds COVID Recovery but May Not Prevent Hospitalizations in Vaccinated Adults

Two 2026 trials found Paxlovid doesn't significantly cut hospitalization in vaccinated high-risk adults. Here's who still benefits and what the evidence actually says.

Medical Daily

CRISPR Gene Editing Achieves a Functional Cure for Sickle Cell Disease in 96 Percent of Patients — RUBY Trial Results in the New England Journal of Medicine Are Historic

The RUBY Trial (NEJM, April 2026): CRISPR-Cas12a gene editing therapy reni-cel (renizgamglogene autogedtemcel) achieved a functional cure in 27 of 28 (96%) severe sickle cell disease patients, with no painful crises for up to two years after treatment. Led by Dr. Rabi Hanna at Cleveland Clinic.

Medical Daily

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Finerenone Kidney Drug Shown to Protect Heart and Kidneys in Millions More Patients After Three Major 2026 Studies

Three major studies published in NEJM, JAMA, and The Lancet in June 2026 show finerenone protects kidneys and hearts in non-diabetic CKD patients, expanding its potential reach to millions.

Medical Daily

Breakthrough Drug Finerenone Now Proven to Protect the Kidneys and Heart in Millions More Patients Than Doctors Thought — Houston's CKD Patients Stand to Benefit Most

Major June 2026 studies show finerenone slows kidney disease and cuts heart failure risk even in patients without diabetes — expanding its benefit to millions. Houston has one of the highest CKD rates in Texas.

Medical Daily

HRT patches to treat prostate cancer – here’s how it works

Women’s HRT patches can treat prostate cancer just as effectively as standard hormone injections – but with fewer of the worst side-effects – according to a large UK trial published in the New England Journal of Medicine. The finding could change how men with prostate cancer that has spread beyond…

The Conversation

HRT patches for menopause ‘can help treat prostate cancer’ – but there is one main side effect

Patches that lower testosterone by delivering oestradiol, a form of oestrogen, through the skin were just as effective as injections at preventing the cancer from spreading

The Independent UK

Tooth-in-eye surgery, 'blood chimerism,' and a pregnancy from oral sex: 12 wild medical cases we covered in 2025

Here are a dozen strange and interesting tales from the medical literature.

LiveScience

New cancer therapy brings remission for patients with deadly T-cell leukaemia

A small group of patients with an otherwise incurable form of T‑cell leukaemia have seen their cancer driven into remission by an innovative form of immune therapy.

The Conversation

How RFK Jr is systematically undermining vaccines around the world

Vaccines are one of the greatest public health success stories of all time. Over the past 50 years, they’ve saved an estimated 154 million lives. But in the US, both access to vaccines and public trust in them are being systematically undermined – not by conspiracy theorists online, but from…

The Conversation

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LiveScience

Weird swelling of man's fingers and toes revealed cancer had 'completely replaced' the bones with lesions

Marked swelling in a man's finger and big toe was a symptom of late-stage cancer.

LiveScience

8 babies spared from potentially deadly inherited diseases through new IVF 'mitochondrial donation' trial

A groundbreaking trial in the U.K. has released data on eight babies born through a special IVF procedure to lower their risk of mitochondrial DNA disease.

LiveScience

Man's body crawling with parasitic worms after infected kidney transplant at US hospital

A second transplant patient also became infected, leading their doctors to surmise that their new kidneys were likely to blame.

The Independent UK

Trump officials set new requirements for COVID vaccines in healthy adults and children

Federal health officials will no longer routinely approve annual COVID-19 shots for younger adults and children who are healthy

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The Conversation

Americans die earlier at all wealth levels, even if wealth buys more years of life in the US than in Europe

Americans at all wealth levels are more likely to die sooner than their European counterparts, with even the richest U.S. citizens living shorter lives than northern and western Europeans. That is the key finding of our new study, published in the New England Journal of Medicine.

The National (Scotland)

Cass Review of trans care 'transgresses medical law and policy', US experts claim

THE Cass Review into transgender care for young people “transgresses medical law, policy, and practice”, US experts have claimed ...

LiveScience

'Red balloon' sprouts from baby's back due to birth defect

The newborn had a birth defect that left a gap in his lower spine, through which tissue pushed out and formed a giant, red, balloon-like structure.

The Guardian - US

Health experts rally for ‘call to arms’ to protect children from toxic chemicals

In new paper in the New England Journal of Medicine, leading researchers to propose action to protect kids

The Times of India

100% effective HIV prevention shots offer breakthrough in fight against AIDS, says study

In a breakthrough development for curbing the spread of AIDS, twice-yearly shots have demonstrated a remarkable 100% effectiveness in preventing new infections among women, according to a study released on Wednesday and published in the New England Journal of Medicine.

LiveScience

Tuberculosis triggered giant, crusty wart to sprout on man's hand

Around 20% of cases of tuberculosis affect organs other than the lungs, and some can cause warty plaques on the skin.

International Business Times

Diabetes Drug Shows Promise Against Parkinson's In Clinical Study

A drug used to treat diabetes slowed the progression of motor issues associated with Parkinson's disease, a study published in the New England Journal of Medicine said Wednesday.

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