Keeping an eye out for charm locations in Resident Evil Requiem will give you an advantage over the zombies trying to munch on your face, especially on higher difficulties, and especially when playing as Grace. Since the FBI agent is a bit weak early on, charms can be a decent way to buff her otherwise lackluster offensive capabilities.
Leon doesn't need as much help in that department, but you can still use charms to buff his weapons and tweak his playstyle slightly. There are nine charms in Resident Evil Requiem, unless there are further secret ones that only appear after specific challenges that I didn't find. Here's where to get them all.
