Flying first class starts making financial sense when the extra comfort costs little relative to your wealth, income, and other priorities. There is no magic net worth that makes an expensive plane ticket harmless, and a million-dollar portfolio does not automatically make champagne at 35,000 feet a sensible purchase.
The more revealing question is what the upgrade costs you beyond the flight itself. That money could fund another vacation, grow in an investment account, or cover several months of ordinary expenses. First class becomes easier to justify when the premium buys something you genuinely value without crowding out those alternatives.