I broke my hand about ten years ago, and my wrist has never been quite right since. It's achy and stiff when held at an angle (or only moving slightly) for too much time, a problem I generally only run into when stress-testing gaming mice over longer periods of play. I was skeptical when the Keychron M5 showed up at my door, though cautiously optimistic.
We've all had friends waxing on about the benefits of vertical mice, and I've considered joining the gang a few times over the years. I never quite pulled the trigger but, after two weeks with this lop-sided fella, I can see the benefits - in some lights.
