As anyone who sim races on a regular desk setup will tell you, compromises must be made. While most of the best racing wheels will come with desk clamps for the wheelbase, what you won't realise until you use one for yourself is the amount of self-adjustment you'll need to perform on the regular to keep yourself in an optimum position.
For a start, there's your desk chair. Chances are it doesn't lock in terms of spinning movement, which means a decent wheel with good feedback will try and turn you around its axis as you fight against the torque, requiring quite a bit of core stability to maintain a good position. There's also the angle itself, which, unless you elevate your pedal set or are a particular fan of Euro Truck Simulator, won't feel very car-like.
