Joe Root revived England's hopes of forcing a series-levelling win in the fourth Test by removing Australia century-maker Marnus Labuschagne on Saturday's rain-marred fourth day.
Australia were 214-5 in their second innings at tea, still 61 runs behind England's first-innings 592.
England, currently 2-1 down in the five-match series, must win at Old Trafford if they are to maintain their hopes of regaining the Ashes.