Richmond champion Dustin Martin and Hawthorn skipper James Sicily are among the big-name outs for round 17, but Melbourne forward Jake Melksham has been named to return from his ACL tear.
In other notable selection calls, Dylan Shiel is back to inspire Essendon, Brennan Cox and Michael Walters return for Fremantle, and Western Bulldogs forward Cody Weightman is injured again.
