The Yamaha rider snatched the lead off the line from second on the grid and quickly pulled a half-second gap to the chasing Ducati of Francesco Bagnaia, before the Italian crashed out at the start of lap four.
It has all but ended Bagnaia's hopes of the championship in 2022 as he slips to 91 points adrift of Quartararo, as the Frenchman's other main threats in Aleix Espargaro struggled to a distant fourth on his Aprilia and Gresini's Enea Bastianini was only 10th.
